Enclomiphene
Also known as: Androxal
Enclomiphene is the trans-stereoisomer of clomiphene citrate, a non-steroidal selective estrogen receptor modulator (SERM) that stimulates endogenous testosterone production. It is not a peptide, but is widely tracked in the peptide and TRT community as an off-label, compounded alternative to testosterone replacement therapy for men who wish to preserve fertility. Clomiphene itself is a ~60:40 mixture of enclomiphene (trans, estrogen-antagonist) and zuclomiphene (cis, weak long-acting estrogen-agonist); isolating the trans-isomer is intended to deliver the HPG-axis effect without the zuclomiphene-driven side effects.
Pricing for Enclomiphene
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No COAs on file for Enclomiphene
No third-party tests indexed yet. Phase 2 will surface more vendor evidence as the dataset grows.
28 citations indexed for Enclomiphene
Study · 2026
Changes in Serum Testosterone After Sublingual Enclomiphene Citrate Combined With a Mineral Oxide Delivery System: A Retrospective Case Series of 15 Men
Background Declining testosterone levels in adult males represent a significant clinical burden.
Study · 2026
British Society of Sexual Medicine: Position Statement for the Potential Use of Enclomiphene in the Treatment of Male Hypogonadism
review · 2026
Treatment Options for Improving The Semen Quality in Obese Men: A Scoping Review
Obesity is a significant factor affecting male fertility. Infertility in obese men often accompanies with metabolic dysfunction and differs from idiopathic male infertility (MI) in treatment approaches. This scoping review summarizes published treatment options for affecting the semen quality in obese men.
review · 2025
Preserving spermatogenesis in testosterone deficiency: innovations in replacement and stimulatory therapies
The rising prevalence of testosterone deficiency has led to increased use of exogenous testosterone therapy, including among men desiring fertility. Conventional testosterone replacement therapies (TRT) restore serum testosterone but suppress gonadotropins, resulting in impaired spermatogenesis.
review · 2025
Comment on Clomiphene or enclomiphene citrate for the treatment of male hypogonadism: a systematic review and meta-analysis of randomized controlled trials
meta-analysis · 2025
Clomiphene or enclomiphene citrate for the treatment of male hypogonadism: a systematic review and meta-analysis of randomized controlled trials
Objective This study aimed to evaluate the efficacy and safety of selective estrogen receptor modulators (SERMs), specifically clomiphene and enclomiphene, in treating men with functional hypogonadism.