MK-677
Also known as: Ibutamoren
MK-677 (ibutamoren, MK-0677, L-163,191) is an orally active, non-peptide small-molecule growth hormone secretagogue developed by Merck in the 1990s. It is a spiropiperidine ghrelin-receptor (GHSR-1a) agonist — not a peptide and not a SARM, though it is commonly misclassified as both in grey-market retail. Merck discontinued development after mixed efficacy and adverse metabolic / cardiovascular findings; it is not FDA-approved.
Pricing for MK-677
Live vendor pricing, normalized to $/mg so sizes compare fairly — fused with each seller's Merit trust score and latest independent COA purity. Prices refresh daily.
COAs for MK-677
2 third-party tests across 2 vendors. Each card links to the full report.
21 citations indexed for MK-677
case-report · 2026
Spontaneous Splenic Rupture in a Patient With Recent Use of Performance-Enhancing Compounds: A Case Report and Literature Review
Atraumatic splenic rupture (ASR) is a rare but life-threatening surgical emergency that most commonly occurs in pathologically abnormal spleens. We present a unique case of ASR in a middle-aged man with recent use of performance-enhancing compounds, managed with both embolization and surgery.
animal · 2026
Acute stress suppresses hunger-driven food seeking through PVN activation: Reversal by anxiolytic drug and ghrelin receptor agonist, with anxiolytic-like effects of refeeding
Feeding behavior is influenced by both metabolic drive and emotional context, yet how acute stress interferes with hunger-driven motivation remains poorly understood.
Study · 2026
Knowing the minimal detectable dose can facilitate the interpretation of a hair test result: II. Case example with ibutamoren (MK-677), a growth hormone secretagogue
Background and aims On numerous occasions during hearings at the Court of Arbitration for Sport (CAS), it has been advocated by the anti-doping authorities that the results of hair tests should be interpreted with utmost precautions. This was due to the lack of data for the interpretation of the results.
Study · 2026
Injuries, Injections, and Internet Forums: A Qualitative Study of Reddit User Perspectives on Peptide Therapy After Orthopaedic Surgery
review · 2026
Systematic review of undeclared prohibited substances and pharmacological adulterants in dietary supplements: prevalence, detection, and risks in sport
Introduction The proliferation of dietary supplement use among athletes has heightened concerns over inadvertent doping due to contamination with substances prohibited by the World Anti-Doping Agency (WADA) and other undeclared pharmacological adulterants.
review · 2026
Insulin-like growth factor 1 associated research in Alzheimer's disease: an exploratory trends analysis
Background Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive impairment and behavioral deterioration. In recent years, the role of the insulin-like growth factor-1 (IGF-1) signaling pathway in the pathological process of AD has received increasing attention.