Adipotide
Also known as: FTPP
Adipotide (FTPP) is a chimeric peptidomimetic developed in the Arap/Pasqualini lab (originally at MD Anderson) that couples a 9-residue homing motif (CKGGRAKDC) — isolated by in vivo phage display as a ligand for prohibitin on white-adipose-tissue vasculature — to the D-amino-acid pro-apoptotic domain D(KLAKLAK)2. It is an experimental research compound, NOT FDA-approved for any indication. A clinical-development program in prostate-cancer-associated obesity reached early-phase testing and was ultimately discontinued.
Pricing for Adipotide
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COAs for Adipotide
2 third-party tests across 2 vendors. Each card links to the full report.
12 citations indexed for Adipotide
review · 2025
Advances and challenges of targeting epicardial adipose tissue (EAT) and perivascular adipose tissue (PVAT)
Clinical consensus statements have been issued for various adipose tissues (ATs), particularly regarding the diagnostic value of epicardial AT (EAT) and perivascular AT (PVAT) in cardiovascular disease.
review · 2024
Prohibitions in the meta-inflammatory response: a review
Prohibitins are the central regulatory element of cellular homeostasis, especially by modulating the response at different levels: Nucleus, mitochondria and membranes.
review · 2023
Encapsulated Peptides and Proteins with an Effect on Satiety
The world scenario has undergone a nutritional transition in which some countries have left the reality of malnutrition and now face an epidemic of excess body weight. Researchers have been looking for strategies to reverse this situation. Peptides and proteins stand out as promising molecules with anti-obesity action.
review · 2023
Peptides as Therapeutic Agents: Challenges and Opportunities in the Green Transition Era
Peptides are at the cutting edge of contemporary research for new potent, selective, and safe therapeutical agents. Their rise has reshaped the pharmaceutical landscape, providing solutions to challenges that traditional small molecules often cannot address.
animal · 2022
Endothelial Prohibitin Mediates Bidirectional Long-Chain Fatty Acid Transport in White and Brown Adipose Tissues
The function of prohibitin-1 (PHB1) in adipocyte mitochondrial respiration, adaptive thermogenesis, and long-chain fatty acid (LCFA) metabolism has been reported. While intracellular PHB1 expression is ubiquitous, cell surface PHB1 localization is selective for adipocytes and endothelial cells of adipose tissue.
review · 2021
Role of Prohibitins in Aging and Therapeutic Potential Against Age-Related Diseases
A decline in mitochondrial function has long been associated with age-related health decline. Several lines of evidence suggest that interventions that stimulate mitochondrial autophagy (mitophagy) can slow aging and prolong healthy lifespan.