Epithalon
Also known as: Epitalon (AEDG, synthetic analog of Epithalamin)
Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Khavinson as an analog of the bovine pineal extract Epithalamin. It is a research-only bioregulator — not FDA-approved — investigated for claimed telomerase activation and circadian/melatonin effects, with evidence limited primarily to Khavinson-group studies.
Who's worth your money for Epithalon
Every current seller, ranked by independent evidence — Merit Score, latest COA purity, and live $/mg (size-normalized). Prices refresh daily. Rankings are never paid.
Top Merit pick
Highest Merit Score (99) of 22 scored sellers
$32.99 · 10mg · 99.9% purity
Best value after code
$0.04/mg effective with 15% code
$0.45 · 10mg · 99.6% purity
Most tested
6 independent COAs on file
$94.97 · 20mg · 99.8% purity
Average price
$3.36/mg
Sellers
79
45-day trend
-2.1%
64 of 79 sellers have a current price· 33 stale hidden· 9 unverified hidden
Top Merit pick
🇺🇸 Glacier Aminos99✓ verified at source · just now
$3.30/mg -1.7% vs avg$32.99
10mg
- 🇺🇸 Hydro Research Peptides97
✓ verified at source · just now
$0.04/mg -98.7% vs avg$0.45
10mg
- 🇺🇸 BioLongevity Labs96
✓ verified at source · just now
$4.75/mg +41.5% vs avg$94.97
20mg
- 🇺🇸 Licensed Peptides95
✓ verified at source · just now
$1.84/mg -45.2% vs avg$91.99
50mg
- 🇺🇸 Polaris Peptides90
✓ verified at source · just now
$3.50/mg +4.3% vs avg$35.00
10mg
- 🇺🇸 Soma Peptides89
✓ verified at source · just now
$0.78/mg -76.8% vs avg$39.00
50mg
- 🇺🇸 Peptidology89
✓ verified at source · just now
$4.95/mg +47.4% vs avg$49.49
10mg
- 🇺🇸 Ruo Bio88
✓ verified at source · just now
$3.80/mg +13.2% vs avg$38.00
10mg
no purity - True Peptide82
✓ verified at source · just now
$3.20/mg -4.7% vs avg$32.00
10mg
- 🇺🇸 Southern Aminos82
✓ verified at source · just now
$3.38/mg +0.6% vs avg$33.75
10mg
no purityBuy code MERIT · 15% off
Prices observed from public storefronts (last 24h), normalized to $/mg. "Evidence" is Merit's 0–100 Merit Score, derived only from observable verification evidence (methodology on /about); "Purity" is the latest independent COA. Some buy links are affiliate links — Merit may earn a commission at no extra cost to you, and where a vendor offers one, the code shown gets you a discount at their checkout. Affiliate status never affects price data, ranking, or the Merit Score (full policy on /disclosure). Research use only.
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About Epithalon
CAS
307297-39-8
Molecular formula
C14H22N4O9
Sequence
AEDG
Typical dose range
5–10 mcg/day subcutaneous or intranasal, typically in cycles of 10–20 days; human clinical studies used 0.5 mg/day sublingually or 5 mcg parabulbarly
Half-life
~30 minutes (estimated; formal pharmacokinetic data limited in published literature)
COAs for Epithalon
125 third-party tests across 36 vendors. Each card links to the full report.
For
Epithalon
by Ion Peptide· batch EP50-02032026
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Epithalon
by Ion Peptide· batch ET50-06242026
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Epithalon
by Ion Peptide· batch ET50-06242026
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Epithalon
by Peptide Supply Co.· batch ET50-06032026
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Epithalon
by True Peptide· batch EPIT-002-TPL
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Epithalon
by Profound Aminos· batch Blue Cap
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Epithalon
by OROS Research· batch OR-LPEPI10-526-B2
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Epithalon
by Profound Aminos
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Epithalon
by Peptide Partners· batch ET202604
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Epithalon
by Crush Research· batch CRET-50-0212-1
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Epithalon
by Ion Peptide· batch ET50-05042026
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Epithalon
by NG Peptide· batch EP50-06
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Epithalon
by BioLongevity Labs· batch 9-3-46146
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Epithalon
by Real Peptides· batch Orange Cap
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Epithalon
by Lumi Peptides· batch LPEP50-001
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Epithalon
by Verified Peptides· batch cmp4wgbkb004jx7rxdpeilkwp
For
Epithalon
by Verified Peptides· batch cmp4wgbn6004kx7rx72c6lhyu
For
Epithalon
by Verified Peptides· batch cmp4wgbpl004lx7rxfa45zj6b
For
Epithalon
by Peptide Plugs· batch 115-B-DK
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Epithalon
by Qihang Peptide· batch 4
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Epithalon
by OROS Research· batch OR-LPEPI10-326-B2
For
Epithalon
by Glacier Aminos· batch EPI10GA-02
For
Epithalon
by Amino Club· batch EPI0001
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Epithalon
by Peptidology· batch 1673
12 citations indexed for Epithalon
review · 2026
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions
Therapeutic peptides are emerging as promising adjuncts in the management of orthopaedic injuries, grounded in their ability to modulate molecular signaling networks central to cellular medicine.
review · 2026
Therapeutic peptides in gerontology: mechanisms and applications for healthy aging
Background Peptide therapeutics represent an emerging frontier in gerontological medicine, targeting fundamental hallmarks of aging including metabolic dysfunction, telomere attrition, tissue repair impairment, and hormonal decline.
meta-analysis · 2026
Efficacy and Safety of Melatonin in Migraine Prophylaxis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Background Migraine is a chronic, disabling brain disorder. Melatonin, a circadian regulator with anti-inflammatory and antinociceptive actions, has been proposed for migraine prevention. We evaluated the efficacy and safety of melatonin for prophylaxis.
review · 2025
Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties
Epitalon, also known as Epithalon or Epithalone, is a tetrapeptide, Ala-Glu-Asp-Gly (AEDG), which was synthesized based on the amino acids composition of Epithalamin, a bovine pineal gland extract, prior to its discovery in pineal gland polypeptide complex solution.
Study · 2025
Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity
Epitalon, a naturally occurring tetrapeptide, is known for its anti-aging effects on mammalian cells. This happens through the induction of telomerase enzyme activity, resulting in the extension of telomere length. A strong link exists between telomere length and aging-related diseases.
review · 2024
[Peptidergic regulation of expression of cellular aging marker proteins in buccal epithelium.]
The review presents the results of long-term research conducted by the staff of the Saint-Petersburg Institute of Bioregulation and Gerontology, dedicated to the study of the biological activity of peptide bioregulators at all levels of a living organism's organization.