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Growth Hormone Secretagogues

Humanin

Also known as: HN

Humanin is a mitochondrial-derived peptide encoded within the 16S ribosomal RNA gene. It was discovered through its ability to protect neurons from Alzheimer's disease-related toxicity and is studied for neuroprotection, metabolic regulation, and anti-aging applications.

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Research depth

20 citations indexed for Humanin

All research on Humanin →

animal · 2026

Humanin as a Molecular Indicator of Semen Quality and Cryotolerance in Crossbred Cattle

The present study aimed to assess the presence of humanin in the sperm of crossbred cattle bulls using immunocytochemistry and to evaluate its potential as a semen quality marker.

Study · 2026

Humanin-G protects septic ARDS by mediating mitochondrial function in lung vascular endothelial cells

Recent investigations show that mitochondrial impairment significantly contributes to endothelial damage in septic acute respiratory distress syndrome (ARDS).

Study · 2026

Circulating Humanin Improves the Prognostic Accuracy of Cardiovascular Risk Models in Chronic Hemodialysis Patients

Introduction Cardiovascular morbidity and mortality (CVMM) remain highly prevalent among end-stage kidney disease (ESKD) patients undergoing chronic hemodialysis (HD). Nevertheless, risk prediction in this setting is limited by the complexity of factors involved and the individual patients' characteristics.

Study · 2026

Humanin improved the rotenone-induced reactive oxygen species formation in PC12 cells by modulating the SIRT3/Nrf2/HO-1 signaling pathway

ObjectiveMitochondrial dysfunction is the key factor in rotenone-induced neurotoxicity in dopaminergic neurons.

Study · 2026

Humanin as an evolutionarily tuned mitochondrial peptide: Insights from mammalian oxidative stress diversity

Humanin is a mitochondrial-derived peptide with cytoprotective properties, but how it has evolved in response to different oxidative stress levels in mammals is not fully understood. This study examines how Humanin sequences have adapted to species-specific metabolic and environmental pressures.

Study · 2026

Mitochondrial derived peptide humanin improved semen quality, semen freezability, antioxidant status and in-vitro fertility in crossbred bull

The sperm quality, freezability, and fertility of crossbred bulls exhibit significant unpredictability, which consequently impacts the breeding program.