Matrixyl
Also known as: Palmitoyl Pentapeptide-4, Palmitoyl Pentapeptide-3, Pal-KTTKS, Palmitoyl-Lys-Thr-Thr-Lys-Ser
Matrixyl is the trade name for palmitoyl pentapeptide-4 (Pal-KTTKS), a topically applied cosmetic peptide consisting of the matrikine pentapeptide KTTKS — a subfragment of type I procollagen — conjugated to palmitic acid to improve skin penetration. It is marketed to stimulate fibroblast production of collagen, elastin, and other extracellular-matrix components, thereby reducing the appearance of fine lines and wrinkles. In the U.S. it is regulated as a cosmetic ingredient and is NOT an FDA-approved drug.
Who's worth your money for Matrixyl
Every current seller, ranked by independent evidence — Merit Score, latest COA purity, and live $/mg (size-normalized). Prices refresh daily. Rankings are never paid.
Top Merit pick
Highest Merit Score (95) of 2 scored sellers
$129 · 10mg · 99.7% purity
Best value
Lowest $/mg among scored sellers
$49.99 · 10mg · 99.1% purity
Average price
$4.93/mg
Sellers
7
45-day trend
+6.6%
4 of 7 sellers have a current price· 2 unverified hidden
Top Merit pick
🇺🇸 Ion Peptide95✓ verified at source · 9h ago
$12.90/mg +161.9% vs avg$129
10mg
- Modern Research Peptides82
✓ verified at source · 8h ago
$5.00/mg +1.5% vs avg$49.99
10mg
Prices observed from public storefronts (last 24h), normalized to $/mg. "Evidence" is Merit's 0–100 Merit Score, derived only from observable verification evidence (methodology on /about); "Purity" is the latest independent COA. Some buy links are affiliate links — Merit may earn a commission at no extra cost to you, and where a vendor offers one, the code shown gets you a discount at their checkout. Affiliate status never affects price data, ranking, or the Merit Score (full policy on /disclosure). Research use only.
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About Matrixyl
CAS
214047-00-4
Molecular formula
C39H75N7O10
Sequence
KTTKS
Typical dose range
Topical only; commonly formulated in cosmetics around 3–8% of the supplier's diluted peptide solution. Not dosed systemically.
Half-life
Not well characterized for topical use; subject to dermal peptidase degradation.
Common research uses
Safety notes
Regulated by the FDA as a cosmetic ingredient (topical), not approved as a drug; anti-aging efficacy evidence is limited and largely supplier-derived. Generally well tolerated topically. Not intended for injection. Not a WADA-prohibited substance.
Reconstitution
Supplied as a powder or pre-diluted cosmetic-grade solution for incorporation into topical formulations; not reconstituted for injection.
COAs for Matrixyl
4 third-party tests across 2 vendors. Each card links to the full report.
For
Palmitoyl Pentapeptide-4
by Ion Peptide· batch PP1G-05162026
For
Matrixyl
by Ion Peptide· batch MATRIX-04202026
For
Matrixyl
by Modern Research Peptides· batch MWCHJ462
For
Matrixyl
by Ion Peptide· batch MATRIX-04202026
12 citations indexed for Matrixyl
animal · 2026
Permeation behaviour of cosmetic actives into the human stratum corneum
Characterising the permeation of cosmetic actives through human skin is important for understanding their functional performance.
case-report · 2026
Use of a Serum With the Infinite Glow® Device Improves Signs of Facial Aging: A Split-Face Case Report Using VISIA Analysis
An increase in wrinkles, laxity, and dyschromia characterizes facial-skin aging. The skin is a natural barrier that prevents or limits the entry of external therapeutic compounds to the body. Enhancing the efficacy of transdermal delivery of anti-aging compounds is a key therapeutic strategy.
review · 2026
Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Clinical Applications, and Future Perspectives
Therapeutic peptides are short chains of amino acids used to treat metabolic and endocrine conditions such as obesity and type 2 diabetes.
Study · 2026
Nanostructure and Collagen-Stimulating Activity of Cationic Pentapeptide Lipopeptides
The self-assembly in aqueous solutions, cytocompatibility, and collagen production of lipopeptide C 16 -KTTKS and a variant with arginine substitution for lysine, C 16 -RTTRS, are investigated. C 16 -KTTKS is known commercially as Matrixyl and is used in cosmetic formulations as it can stimulate collagen production.
review · 2026
Dermocosmetics for Periocular Aging: Evidence, Mechanisms, and Integration with Aesthetic Procedures. A Narrative Review
The periocular area, where facial skin is thinnest and most expressive, is often the first to reveal signs of aging. Aesthetic procedures can correct structural changes, but they do not replace daily, ongoing care.
Study · 2026
A Systematic Review of the Mechanisms and Therapeutic Applications of GHK-Cu (Glycyl-L-Histidyl-L-Lysine-Copper Complex) in Topical Microneedle Delivery: A Case for Expanded Clinical Trials
GHK-Cu, the copper-bound form of the human tripeptide glycyl-L-histidyl-L-lysine has accumulated more than four decades of pre-clinical evidence for tissue regeneration, anti-inflammatory action, antioxidant capacity, and broad gene-expression remodeling.