Tirzepatide
Also known as: Tirzepatide (GIP/GLP-1 dual receptor agonist — Mounjaro, Zepbound)
Tirzepatide is a unimolecular dual GIP and GLP-1 receptor agonist with a half-life of approximately 5 days, enabling once-weekly subcutaneous dosing. It is FDA-approved as Mounjaro for type 2 diabetes (2022), Zepbound for chronic weight management in adults with obesity or overweight with a weight-related comorbidity (2023), and Zepbound for moderate-to-severe obstructive sleep apnea in adults with obesity (2024). It carries a BOXED WARNING for thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Who's worth your money for Tirzepatide
Every current seller, ranked by independent evidence — Merit Score, latest COA purity, and live $/mg (size-normalized). Prices refresh daily. Rankings are never paid.
Top Merit pick
Highest Merit Score (90) of 5 scored sellers
$55.00 · 5mg · 99.9% purity
Best value
Lowest $/mg among scored sellers
$10.00 · 20mg · 99.8% purity
Most tested
4 independent COAs on file
$89.00 · 30mg · 99.6% purity
Average price
$6.28/mg
Sellers
76
45-day trend
+21.7%
69 of 76 sellers have a current price· 64 stale hidden
Top Merit pick
🇺🇸 Polaris Peptides90✓ verified at source · just now
$11.00/mg +75.3% vs avg$55.00
5mg
- 🇺🇸 Blank Peptides81
✓ verified at source · just now
$2.97/mg -52.7% vs avg$89.00
30mg
- 🇺🇸 Bulk Peptides50
✓ verified at source · just now
$19.00/mg +202.8% vs avg$380
20mg
no purity - 🇭🇰 Hkuppeptide49
✓ verified at source · just now
$0.50/mg -92% vs avg$10.00
20mg
- 🇭🇰 zztai Peptide Ltd42
✓ verified at source · just now
$4.67/mg -25.6% vs avg$280
60mg
Prices observed from public storefronts (last 24h), normalized to $/mg. "Evidence" is Merit's 0–100 Merit Score, derived only from observable verification evidence (methodology on /about); "Purity" is the latest independent COA. Some buy links are affiliate links — Merit may earn a commission at no extra cost to you, and where a vendor offers one, the code shown gets you a discount at their checkout. Affiliate status never affects price data, ranking, or the Merit Score (full policy on /disclosure). Research use only.
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About Tirzepatide
CAS
2023788-19-2
Molecular formula
C225H348N48O68
Sequence
YXEGTFTSDYSIXLDKIAQKAFVQWLIAGGPSSGAPPPSamide
Typical dose range
2.5–15 mg once weekly subcutaneous injection (research studies mirror clinical titration: start 2.5 mg/week, escalate by 2.5 mg every 4 weeks to max 15 mg/week)
Half-life
~5 days (~120 hours)
COAs for Tirzepatide
449 third-party tests across 55 vendors. Each card links to the full report.
For
Tirzepatide
by Crush Research· batch CR-2XAG-60-2607-Purple
For
Tirzeptide
by Ignite Peptides· batch IP-2607-127
For
Tirzepatide
by Ignite Peptides· batch IP-2607-797
For
Tirzepatide
by NG Peptide· batch TRZ40-15
For
Tirzepatide
by Hydro Research Peptides· batch HR-2026-3814
For
Tirzepatide
by NG Peptide· batch TRZ20-14
For
Tirzepatide
by NG Peptide· batch TRZ20-14
For
Tirzepatide
by Aspire Peptides· batch TR10-032026-1
For
Tirzepatide
by Aspire Peptides· batch TR15-032026-1
For
Tirzepatide
by Polaris Peptides· batch POL-T10-19
For
Tirzepatide
by Orbitrex Peptides· batch 2G30726
For
Tirzepatide
by Ion Peptide· batch ION2T20-06242026
For
Tirzepatide
by Profound Aminos· batch Clear Cap/Bronze Crimp
For
Tirzepatide
by Blank Peptides· batch GT10-062026-6
For
Tirzepatide
by Soma Peptides· batch TIXH0062661
For
Tirzepatide
by Peptide Partners· batch SPL-4130
For
Tirzepatide
by NG Peptide· batch TRZ30-13
For
Tirzepatide
by NG Peptide· batch TRZ30-13
For
Tirzepatide
by Peptide Plugs· batch 005-B-SM
For
Tirzepatide
by NG Peptide· batch TRZ60-04
For
Tirzepatide
by Voltera Sciences· batch TR60.05.28.26
For
Tirzepatide
by Soma Peptides· batch TILX052678
For
Tirzepatide
by Blank Peptides· batch GT30-A5-062026-4
For
Tirzepatide
by EZ Peptides· batch EZP-2P2005162026-04
23 citations indexed for Tirzepatide
Study · 2026
Trends in Cost of Care With Tirzepatide in Adults Aged Over 55 Years With Obesity or Overweight Without Diabetes: A Matched Cohort Analysis
Aims Compare healthcare cost trends among older adults with obesity or overweight treated with tirzepatide versus no treatment. Materials and methods Retrospective cohort study using real-world data from US Komodo Research Dataset, 8 November 2022 to 30 September 2025.
rct · 2026
Liver Fat Changes in Patients With Type 2 Diabetes by Presence of Genetic Hepatic Steatosis: A Post Hoc Analysis of SURPASS-3 MRI
The patatin-like phospholipase 3 (PNPLA3) I148M genetic variant is highly associated with steatotic liver disease.
rct · 2026
Achieving the triple endpoint of body weight reduction thresholds, systolic blood pressure reduction ≥5 mmHg and non-HDL cholesterol <130 mg/dL with tirzepatide in people with obesity: A post hoc analysis from the SURMOUNT trials
Background Modest body weight reduction can greatly improve many health-related outcomes. In the SURMOUNT clinical trial program, once-weekly tirzepatide resulted in substantial body weight reductions in people with obesity, without and with type 2 diabetes.
Study · 2026
Tirzepatide Persistence and Associated Changes in Clinical Outcomes in US Adults With Obesity or Overweight: A 6-Month Claims Database Analysis
Aims Tirzepatide is a once-weekly glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist (GLP-1 RA) approved in the US for the treatment of Type 2 diabetes (T2D), weight loss and obstructive sleep apnoea.
review · 2026
Tirzepatide and SGLT2 Inhibitors for Heart Failure With Preserved Ejection Fraction and Obesity: Entering a New Cardiometabolic Therapeutic Era
Background Heart failure with preserved ejection fraction (HFpEF) accounts for over half of all heart failure hospitalizations, with obesity increasingly recognized as a central driver through expansion of epicardial adipose tissue, chronic low-grade inflammation and obesity-related haemodynamic overload culminating in…
Study · 2026
Predicted 10-Year Cardiovascular Disease Risk Reduction with Tirzepatide Use Over Three Years for Primary Prevention of Cardiovascular Disease in Obesity
Aim This post hoc analysis assessed the durability of tirzepatide for primary cardiovascular disease (CVD) prevention in obesity, based on predicted CVD risk, in the SURMOUNT-1 (SM-1) 3-year study.