Vasoactive Intestinal Peptide (VIP)
Also known as: VIP
Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide of the secretin/glucagon family, widely distributed in the CNS and peripheral nervous system. It is a potent vasodilator, bronchodilator, and immunomodulator. Synthetic VIP (aviptadil) has been investigated in clinical trials for COVID-19-associated acute respiratory failure; it is NOT FDA-approved. Intranasal compounded VIP is used off-label in the controversial 'CIRS' (Chronic Inflammatory Response Syndrome) / mold-illness protocol popularized by Ritchie Shoemaker — CIRS is not a mainstream medical diagnosis.
Who's worth your money for Vasoactive Intestinal Peptide (VIP)
Every current seller, ranked by independent evidence — Merit Score, latest COA purity, and live $/mg (size-normalized). Prices refresh daily. Rankings are never paid.
Top Merit pick
Highest Merit Score (99) of 12 scored sellers
$990 · 200mg · 99.4% purity
Most tested
5 independent COAs on file
$74.97 · 5mg · 99.7% purity
Average price
$8.12/mg
Sellers
16
45-day trend
+5.2%
15 of 16 sellers have a current price· 1 stale hidden· 2 unverified hidden
Top Merit pick
🇺🇸 Peptide Partners99via Disclosed Labs · 1h ago
$4.95/mg -39.1% vs avg$990
200mg
- 🇺🇸 BioLongevity Labs96
via Disclosed Labs · 1h ago
$14.99/mg +84.6% vs avg$74.97
5mg
- 🇺🇸 Profound Aminos95
via Disclosed Labs · 1h ago
$6.00/mg -26.1% vs avg$60.00
10mg
- 🇺🇸 Orbitrex Peptides95
via Disclosed Labs · 1h ago
$9.00/mg +10.8% vs avg$89.99
10mg
no purityBuy Code Orbitrex10 · 10% off - 🇺🇸 NG Peptide86
via Disclosed Labs · 1h ago
$4.50/mg -44.6% vs avg$45.00
10mg
no purity - 🇺🇸 Simple Peptide85
via Disclosed Labs · 1h ago
$10.40/mg +28% vs avg$52.00
5mg
- Peptide Supply Co.83
via Disclosed Labs · 1h ago
$4.50/mg -44.6% vs avg$450
100mg
no purity - Modern Research Peptides82
via Disclosed Labs · 1h ago
$6.00/mg -26.1% vs avg$59.99
10mg
no purity - True Peptide82
via Disclosed Labs · 1h ago
$12.00/mg +47.7% vs avg$60.00
5mg
no purityBuy Code MERIT · 15% off - 🇺🇸 Blank Peptides81
via Disclosed Labs · 1h ago
$7.50/mg -7.7% vs avg$75.00
10mg
Prices observed from public storefronts (last 24h), normalized to $/mg. "Evidence" is Merit's 0–100 Merit Score, derived only from observable verification evidence (methodology on /about); "Purity" is the latest independent COA. Some buy links are affiliate links — Merit may earn a commission at no extra cost to you, and where a vendor offers one, the code shown gets you a discount at their checkout. Affiliate status never affects price data, ranking, or the Merit Score (full policy on /disclosure). Research use only.
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About Vasoactive Intestinal Peptide (VIP)
CAS
40077-57-4
Molecular formula
C147H237N43O43S
Sequence
HSDAVFTDNYTRLRKQMAVKKYLNSILN
Typical dose range
50 mcg per nostril (400 mcg/day) intranasal 4x daily (Shoemaker/CIRS protocol); 25–50 mcg/kg inhaled q4–6h for pulmonary research
Half-life
~1–2 minutes (plasma, IV/physiological conditions)
COAs for Vasoactive Intestinal Peptide (VIP)
20 third-party tests across 10 vendors. Each card links to the full report.
For
Vasoactive Intestinal Peptide (VIP)
by Crush Research· batch CRVIP-10-2604-1
For
Vasoactive Intestinal Peptide (VIP)
by Simple Peptide· batch VP5-032026-1
For
Vasoactive Intestinal Peptide (VIP)
by BioLongevity Labs· batch 31-3-46041
For
Vasoactive Intestinal Peptide (VIP)
by Mile High Compounds· batch VIP-010-MH-01
For
Vasoactive Intestinal Peptide (VIP)
by Glacier Aminos· batch VIP10GA01
For
Vasoactive Intestinal Peptide (VIP)
by BioLongevity Labs· batch 31-3-45951
For
Vasoactive Intestinal Peptide (VIP)
by BioLongevity Labs· batch cmojb76ku0193kirx6m3i9gri
For
Vasoactive Intestinal Peptide (VIP)
by Skye Peptides· batch VIP25-05-002
For
Vasoactive Intestinal Peptide (VIP)
by Peptide Partners· batch VP20250511
For
Vasoactive Intestinal Peptide (VIP)
by Profound Aminos· batch 2025-05-19
For
Vasoactive Intestinal Peptide (VIP)
by Verified Peptides· batch cmojb6azj012wkirxcsj3o26v
For
Vasoactive Intestinal Peptide (VIP)
by Glacier Aminos· batch VIP10GA-02
Purity not on file
For
Vasoactive Intestinal Peptide (VIP)
by Certified Peptides· batch VP10-002
Purity not on file
For
Vasoactive Intestinal Peptide (VIP)
by Mile High Compounds· batch VIP-010-MH-01
Purity not on file
For
Vasoactive Intestinal Peptide (VIP)
by Mile High Compounds· batch VIP-010-MH-01
Purity not on file
For
Vasoactive Intestinal Peptide (VIP)
by BioLongevity Labs· batch 31-3-45951
Purity not on file
For
Vasoactive Intestinal Peptide (VIP)
by BioLongevity Labs· batch cmojb76h30192kirxwdp6g317
Purity not on file
For
Vasoactive Intestinal Peptide (VIP)
by Skye Peptides· batch VIP25-05-002
Purity not on file
For
Vasoactive Intestinal Peptide (VIP)
by Skye Peptides· batch VIP25-05-002
Purity not on file
For
Vasoactive Intestinal Peptide (VIP)
by Peptide Partners· batch cmojb223b003fkirx4s4gkb1s
20 citations indexed for Vasoactive Intestinal Peptide (VIP)
case-report · 2026
Vasoactive Intestinal Peptide (VIP)-Secreting Neuroblastic Tumors in Children Presenting With Chronic Secretory Diarrhea: A Report of Two Cases
Vasoactive intestinal peptide (VIP)-secreting neuroblastic tumors are rare pediatric neoplasms that may present with chronic secretory diarrhea prior to tumor detection, posing significant diagnostic and therapeutic challenges.
rct · 2026
Acupuncture for Postoperative Gastric Emptying Delay
This multicenter clinical trial, conducted at Qilu Hospital of Shandong University and collaborating institutions, prospectively assesses the efficacy and safety of acupuncture for postoperative delayed gastric emptying.
Study · 2025
Vasoactive Intestinal Peptide (VIP) in COVID-19 Therapy-Shedding of ACE2 and TMPRSS2 via ADAM10
Patients infected with SARS-CoV-2 may develop mild respiratory symptoms but also Acute Respiratory Distress Syndrome (ARDS). Additionally, severe systemic inflammation contributes to morbidity and mortality.
animal · 2025
Vasoactive Intestinal Peptide (VIP) and its Receptors in Adipose Tissue: Implications for Cold Stress Adaptation
Adipose tissue represents an organ that is highly dynamic and contributes toward vital survival events such as immune responses, lactation, metabolism fuel, and thermogenesis.
rct · 2025
Efficacy and Safety of Stapokibart in Non-Allergic Rhinitis With Eosinophilia Syndrome
The goal of this clinical trial is to learn if Stapokibart (CM310) works to treat Non-Allergic Rhinitis with Eosinophilia Syndrome (NARES) in adults. It will also learn about the safety of CM310. The main questions it aims to answer are: Does drug CM310 relieve the symptoms of participants?
rct · 2025
Effect of Non-invasive Neuromodulation on the Quality of Intestinal Cleansing
To clarify whether non-invasive neuromodulation for assisted bowel preparation can improve the quality of bowel preparation, to explore the possible mechanisms by which TEA improves the quality of bowel preparation, and to assess its safety, as well as subjects' tolerance, compliance and satisfaction.